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- Allopathic Formulation - Soft Gel
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Formulations For Prophylactic Use
Formulations for therapeutic use
Herbal formulations
Anti diabetic
Anti ulcerant and anti emetic
 Soft Gel by Therapeutic Category
Soft Gel Formulations
Vitamins
Soft Gel Capsule
Soft gel is regarded as an ideal dosage form for some OTC drugs and prescribed medicines. A survey carried out in the USA shows that 44.2% of the consumers like soft capsule better than other dosage forms. Compared with other dosage forms, it has the advantage of high bioavailability, accurate content, even shape and nice appearance. Soft gel is the best dosage form for aliphatic medicine. Besides, it is also suitable for products of low bioavailability, with a bitter or disagreeable taste, being unstable to light, humidity or heat, or easily oxidized.
- Better protection of active ingredients—hermetically sealed dosage form protects drug from oxidation and degradation.
- Marketplace differentiation—a nearly endless array of shapes, sizes and shell colors helps product stand out from branded or generic competitors.
- Consumer preference—results of studies done through the years show that consumers expressed their preference for softgels in terms of ease of swallowing, perceived speed of delivery, lack of unpleasant odor or taste and modern appearance.
- Tamper evidence—a punctured or otherwise tampered soft gel will leak or become discolored, indicating a potential problem.
- Enhanced bioavailability
- Minimizes patient-to-patient variability
- Possible lowered drug dosing
- Excellent dose uniformity
- Obvious evidence of tampering
- Ability to solubilize a wide range of active ingredients
- Extensive product differentiation possibilities
- Enhanced life-cycle management
As a pharmaceutical company, we have manufactured a variety of medicines in soft gel form and introduced more and more items to supply market
Soft gel capsule can encapsulate oil, liquid, suspension, paste, even powder, into capsules of different shape and different size. Comparing with other dosage forms, it has the advantage of high bioavailability, accurate content, even shape and nice appearance. Soft gel capsule is the best dosage form for oil medicine and health food. Besides, it is also suitable for products of low melting point, low bioavailability, with a bitter or disagreeable taste, being unstable to light, humidity or heat, or easily oxidized. Soft gel capsule form is widely used in medicine, food supplements and cosmetics.
Shell material is mainly comprised of gelatin, glycerin and purified water. Gelatin is one kind of natural protein derived from animal hides or bones. It is by nature a nutritious food. A number of daily foods, such as jelly and candy, are made with gelatin. Glycerin is also a natural product abstracted from vegetable oil through hydrolysis process. It is a widely used food additive. Therefore, shell material itself is a nutritious food.
A survey carried out in America shows that 44.2% of the consumers like Soft gel capsule better than other dosage forms.
Soft gel capsule has the following advantages:
- Absorbed directly and swiftly after disintegrating in the intestine. No dissolving course;
- Accurate content weight;
- High bioavailability;
- Stable and low moisture absorbing;
- Good airtight, masking the disagreeable taste of drugs;
- Easy carrying and nice looking can be made at will into various attractive shapes.
There is a vast range of application for the form of Soft gel capsule:
- Medicine. Most oil drugs, herbal extract and natural products are manufactured into Soft gel capsule.
- Dietary supplement. More and more dietary supplements appear as a Soft gel capsule.
- Food. Breath fresh bead is a Soft gel capsule.
- Cosmetics. Much facial oil, facial cream and hair oil products adopt Soft gel capsule form. In addition, bath oil beads are also Soft gel capsules.
- Amusement: Paintball, some toys and fake blood used in movies.
Soft gel capsule develops rapidly in the world. It is widely used in medicines, nutritional products, cosmetics and home appliances. The United States is the biggest Soft gel capsule manufacturer and seller in the world. Next are Germany and U.K.
Soft gel capsule manufacture requires special technology and equipment. There are fewer factories engaged in manufacture of Soft gel capsules comparing with other dosage forms. Now it is common in the world that professional factories accept other organizations assign to make for them.
To build a Soft gel capsule production line needs big money input and well-trained workforce. Investment is big and recouping period is long. It is not economical to build a production line for just one or a few products. That is why contract manufacturing of Soft gel capsules prevails in the world.
Quality of a Soft gel capsule can be evaluated according to the following criteria:
- Disintegration. This is an important criterion to estimate whether human body will absorb a
Product. Chinese Pharmacopoeia stipulates Soft gel capsule must be completely. Disintegrated
Within 60 minutes, and time required by British Pharmacopoeia and US Pharmacopoeia is within 30 minutes.
- Fill variation, one of the important criteria. Chinese Pharmacopoeia, British
Pharmacopoeia and US Pharmacopoeia have relative requirements. Generally fill
variation should not exceed 7.5% for Soft gel capsule under 500mg, and not exceed 5%
for Soft gel capsule above 500mg. Missing the requirement means that active ingredient
content of a product is not accurate. This will affect the efficacy of the products
- Homogeneity. There are different homogeneity requirements for different Soft gel capsule
products. If a Soft gel capsule, especially that contains solid contents like plant extract,
cannot be emulsified evenly, it means content of active ingredient is not accurate, some
contains more, and some contains less. This will seriously affect efficacy of the product.
All these should be tested with related experimental instruments, and be done by professionals.
Selecting a right contract manufacturer is of critical importance for your success. You need to take into consideration not only the price, but also their production environment. This includes:
- Whether the workshop can meets GMP requirements.
GMP, as a regulation governing the manufacturing of medicine and health food, sets strict
stipulation on the production environment. Being GMP certified means a factory’s
production environment meets the requirements for manufacturing medicine or health
food.
- Whether a factory has necessary test instruments and skilful personnel.
Soft gel capsule manufacturing is a specialized trade. Sufficient test instruments and
qualified technical personnel are closely related to quality of products.
- Quality of production line operators.
Production line operators play an important roll in Soft gel capsule quality. A few key factors
to judge if the operators are qualified include: educational level; experience; job training; and
whether they receive periodic health check-up;
- Whether rules and regulation are complete and effective.
Rules and regulations are very important in controlling quality of products. These may
include: operating procedures for all position and all machines and instruments, cleaning and
management procedures, various records, etc.
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