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| Composition |
| Each 5 ml contains |
| Dried Aluminium Hydroxide Gel BP |
250 mg |
| Magnesium Hydroxide BP |
250 mg |
| Simethicone BP |
50 mg |
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Mode of Action
Being basic compound, aluminum hydroxide and magnesium Hydroxide react with gastric acid to form chloride salts of magnesium, aluminum and water. This reaction neutralizes the acid and raises the pH of the stomach contents. It acts as a demulcent and forms a coating over the ulcer crater and prevents irritation from food contact. Aluminum tends to cause constipation by smooth muscle relaxation, while magnesium may produce diarrhoea by its action as an osmotic purgative. Hence both are combined to equalize each other’s effects. Methyl polysilozane is a silicon polymer, which reduces surface tension and collapse air bubbles. Thus it helps to reduce distension and flatulence.
Pharmacokinetics:
On oral administration, none of the components are absorbed significantly. Some aluminum, which is absorbed, is excreted in the urine (this is impaired in renal failure). It also binds to phosphates in the GIT and prevents its absorption.
Clinical Information
Indications
Symptomatic relief of hyperacidity in
- Acid peptic disease
- Gastritis, gastro oesophageal reflux
- Peptic oesophagitis
- Hiatus hernia
Prophylactic in gastritis and irritation when given with drugs like NSAIDS, steroids.
Dosage
Adult: 10 – 20 ml (2 –4 teaspoons) of liquid antacid – 4 times a day and at bedtime.
Child: 6 – 12 years – 5 ml tds.
Contraindications:
Renal failure (In renal failure patients – systemically absorbed aluminum is not excreted leading to encephalopathy and osteomalacia due to aluminum deposition in target tissue)Hypophosphatemia.
Precautions / Practice Points:
Prolonged use of aluminum containing antacids may cause hypophosphatemia and osteoporosis.
Administration instructions
Liquid – administered 20 minutes to 1 hour after meals and at bedtime.
Tablet - instruct to chew well before swallowing, 4 times a day, 20 minutes to 1 hour after meals and at bedtime.
Drug Interactions:
Non fatal:
Antacids decrease the absorption of tetracyclines, iron salts, ketoconazole, Fluroquinolones, H2 blockers, phenothiazines, phenytoin, diazepam, ACE Inhibitors, isoniazid, rifampicin, ethambutol, ciprofloxacin, norfloxacin, Chloroquine and digoxin.
Adverse Effects:
Common effects: Nausea, vomiting, abdominal pain may occur.
Rare effects: In prolonged use – muscle weakness, fatigue, osteomalacia due to hypohphosphatemia can occur
Presentation
1 x 200 ml bottle
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